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University of Connecticut School of Engineering Cellular Mechanics Laboratory

Publications

  • Z. CHAI, S. Gu, G. LYKOTRAFITIS, 'Dynamics of the axon plasma membrane skeleton', Soft Matter, 19, 2514-2528, (2023).  Article
  • Z. CHAI, A.V. TZINGOUNIS, G. LYKOTRAFITIS, 'The periodic axon membrane skeleton leads to Na nanodomains but does not impact action potentials', Biophysical Journal, 18, 3334-3344, (2022).  Article
  • Y. ZHANG, Z. CHAI, G. LYKOTRAFITIS, 'Deep reinforcement learning with a particle dynamics environment applied to emergency evacuation of a room with obstacles', Physica A, 571 , 125845, (2021).  Article
  • K. PARTOLA and G. LYKOTRAFITIS, 'Assembly for measuring the viscosity of fluids using microchannels', Patent No.: US 10,928,289 B2 , (Feb. 23, 2021).
  • Y. ZHANG, Z. CHAI, Y. SUN, G. LYKOTRAFITIS, 'A deep reinforcement learning model based on deterministic policy gradient for collective neural crest cell migration', arXiv.org, (2020).  Article
  • M. CAUBLE, N. MANCINI, J. KALINOWSKI, G. LYKOTRAFITIS, I.L. MOSS, 'Atomic force microscopy imaging for nanoscale and microscale assessments of extracellular matrix in intervertebral disc and degeneration', JOR Spine, 2020;3:e1125, https://doi.org/10.1002/jsp2.1125 (2020).  Article
  • J. ZHANG, S-M JONES, G. LYKOTRAFITIS and B. ANDEMARIAM, 'Valsartan impedes epinephrine-induced ICAM-4 activation on normal, sickle cell trait and sickle cell disease red blood cells', PLOS ONE, 14, Issue 5, e0216467, (2019).  Article
  • Y. ZHANG, A.V. TZINGOUNIS, and G. LYKOTRAFITIS 'Modeling of the axon plasma membrane structure and its effects on protein diffusion', PLOS Computational Biology, 15, Issue 5, e1007003, (2019).  Article
  • K. ABIRAMAN, A.V. TZINGOUNIS, and G. LYKOTRAFITIS 'KCa2 Channel Localization and Regulation in the Axon Initial Segment', FASEB, , (2018).  Article
  • H. LI, H-Y CHANG, J. YANG, L. LU, and G. LYKOTRAFITIS 'Modeling biological membranes and red blood cells by coarse-grained particle methods', Applied Mathematics and Mechanics, (Special Topic Issue on Theory, Methods and Applications of Mesoscopic Modeling), 39, Issue 1, 3-20, (2018).  Article
  • K. PARTOLA, B. ANDEMARIAM (MD), and G. LYKOTRAFITIS 'Microfluidic Experimental Setup for Adhesion and Recovery Measurements of Red Blood Cells in Sickle Cell Disease', Journal of the Mechanical Behavior of Biomedical Materials, 71, 80-84, (2017).  Article
  • Y. ZHANG, K. ABIRAMAN, H. LI, D.M. PIERCE, A.V. TZINGOUNIS, and G. LYKOTRAFITIS 'Modeling of the axon membrane skeleton structure and implications for its mechanical properties', PLOS Computational Biology, 13, Issue 2, e1005407, (2017).  Article
  • J. ZHANG, K. ABIRAMAN, S-M. JONES, G. LYKOTRAFITIS, and B. ANDEMARIAM (MD) 'Regulation of active ICAM-4 adhesion receptors on normal and sickle cell disease RBCs via AKAPs is revealed by atomic force microscopy', Biophysical Journal, 112, 143-152, (2017).  Article
  • X. LI, M. DAO, G. LYKOTRAFITIS, and G. KARNIADAKIS, 'Biomechanics and biorheology of red blood cells in sickle cell anemia (Review Article)', Journal of Biomechanics , 50, 34-41, (2017).  Article
  • X. LI, H. LI, H-Y CHANG, G. LYKOTRAFITIS, and G. KARNIADAKIS, 'Computational biomechanics of human red blood cells in hematological disorders (Review Article)', ASME Journal of Biomechanical Engineering , 139, 021008, (2017).  Article
  • V.Q. HA and G. LYKOTRAFITIS, 'IMPETUS - Interactive MultiPhysics EnvironmenT for Unified Simulations', Journal of Biomechanics, 49, 4034-4038, (2016).   Download IMPETUS,   Article
  • K. ABIRAMAN, M. SAH, R.S. WALIKONIS, G. LYKOTRAFITIS and A.V. TZINGOUNIS, 'Tonic PKA activity regulates SK channel nanoclustering and somatodendritic distribution', Journal of Molecular Biology , 428, Issue 11, 2521-2537, (2016).  Article
  • H. LI, Y. ZHANG, V. HA and G. LYKOTRAFITIS, 'Modeling of the band-3 proteins diffusion in the normal and defective red blood cell membrane', Soft Matter , 12, 3643-3653, (2016).  Article
  • K. PARTOLA and G. LYKOTRAFITIS, 'FRAME (Force Review Automation Environment): MATLAB-based AFM data processor', Journal of Biomechanics, 49, Issue 7, 1221-1224 (2016).   Download FRAME,  Article
  • H. LI and G. LYKOTRAFITIS, 'Vesiculation of healthy and defective red blood cells', Physical Review E , 92, 012715, (2015).  Article
  • N.J. WANDERSEE, J. MACIASZEK, K.M. GIGER, M.S. HANSON, S. ZHENG, Y. GUO, B. MICKELSON, C.H. HILLERY, G. LYKOTRAFITIS, P.S. LOW, and N. HOGG 'Dietary supplementation with docosahexanoic acid (DHA) increases red blood cell membrane flexibility in mice with sickle cell disease', Blood Cells, Molecules, and Diseases, 54, Issue 2, 183-188, (2015).  Article
  • J. MACIASZEK, K. PARTOLA, J. ZHANG, B. ANDEMARIAM (MD), and G. LYKOTRAFITIS, 'Single-cell force spectroscopy as a technique to quantify human red blood cell adhesion to subendothelial laminin', Journal of Biomechanics, 47, Issue 16, 3855-3861, (2014).  Article
  • H. LI and G. LYKOTRAFITIS, 'Erythrocyte membrane model with explicit description of the lipid bilayer and the spectrin network', Biophysical Journal, 107, Issue 3, 642-653, (2014).  Article
  • J. MACIASZEK, B. ANDEMARIAM (MD), K. ABIRAMAN, and G. LYKOTRAFITIS, 'AKAP-dependent modulation of BCAM/Lu adhesion on normal and sickle cell disease RBCs revealed by force nanoscopy', Biophysical Journal, 106, Issue 6, 1258-1267, (2014).  Article  Cover Picture,  Biophysical Society blog
  • J. MACIASZEK, H. SOH, R.S. WALIKONIS, A.V. TZINGOUNIS and G. LYKOTRAFITIS, 'Topography of native SK channels revealed by force nanoscopy in living neurons', Journal of Neuroscience, 32, Issue 33, 11435-11440 (2012).  Article F1000 Article F1000 Article
  • H. LI , V. HA and G. LYKOTRAFITIS, 'Modeling sickle hemoglobin fibers as one chain of coarse-grained particles', Journal of Biomechanics, 45, Issue 11, 1947-1951 (2012).  Article
  • J. MACIASZEK, B. ANDEMARIAM (MD), G. HUBER, and G. LYKOTRAFITIS, 'Epinephrine modulates BCAM/Lu and ICAM-4 expression on the sickle cell trait red blood cell', Biophysical Journal, 102, Issue 5, 1137-1143 (2012).  Article
  • V. HA and G. LYKOTRAFITIS, 'Agent-based modeling of a multi-room multi-floor building emergency evacuation', Physica A, 391, 2740-2751, (2012).  Article
  • H. LI and G. LYKOTRAFITIS, 'Two-component coarse-grain molecular dynamics model for the human erythrocyte membrane', Biophysical Journal, 102, Issue 1, 75-84, (2012).  Article,  Supporting Material,  Cover Picture,  Biophysical Society blog ,   Top 25 Hottest Articles
  • G. LYKOTRAFITIS, H.G. GEORGIADIS, P.A. GOURGIOTIS, 'Rapid sliding motion of a rigid frictionless indentor with a flat base over a thermoelastic half-space', Archive of Applied Mechanics, Doi: 10.1007/s00419-012-0670-0, (2012).  Author's copy  Article
  • M. BUDYANSKY, C. MADORMO, J. MACIASZEK and G. LYKOTRAFITIS, 'Coherent gradient sensing microscopy (micro-CGS): a microscale curvature detection technique', Optics and Lasers in Engineering, 49, 874-879 (2011).  Article
  • J. MACIASZEK, B. ANDEMARIAM (MD), and G. LYKOTRAFITIS, 'Microelasticity of red blood cells in sickle cell disease', Journal of Strain Analysis for Engineering Design, 44, no. 5, 368-379 (2011).  Article
  • J. MACIASZEK and G. LYKOTRAFITIS, 'Sickle cell trait human erythrocytes are significantly stiffer than normal', Journal of Biomechanics, 44, 657-661 (2011).  Article
  • H. LI and G. LYKOTRAFITIS, 'A coarse-grain molecular dynamics model for sickle hemoglobin fibers', Journal of Mechanical Behavior of Biomedical Materials, 4, 162-173 (2011).  Article
  • H. YUAN, C. HUANG, J. LI, G. LYKOTRAFITIS and S. ZHANG, 'One-particle-thick, solvent-free, coarse-grained model for biological and biomimetic fluid membranes', Physical Review E, 82, 011905 (2010).  pdf
  • S. ZHANG, J. LI, G. LYKOTRAFITIS, G. BAO and S. SURESH, 'Size-dependent endocytosis of nanoparticles', Advanced Materials, 20, 1-6 (2008).  pdf
  • Y. PARK, M. DIEZ-SILVA, G. POPESCU, G. LYKOTRAFITIS, W. CHOI, M. FELD and S. SURESH, 'Cell nanoscale membrane fluctuations is an indicator of pathological state of human red blood cell', PNAS, 105, Issue 37, 13730-13735 (2008). pdf, supp. material
  • J. LI, G. LYKOTRAFITIS, M. DAO and S. SURESH, 'Cytoskeletal dynamics of human erythrocyte', PNAS,104, Issue 12, 4937-4942 (2007).  pdf, supp. material
  • G. LYKOTRAFITIS, A.J. ROSAKIS and G. RAVICHANDRAN, 'Self-healing pulse-like shear ruptures in the laboratory', Science, 313, 1765-1768 (2006). pdf , supp. material
  • G. LYKOTRAFITIS, A.J. ROSAKIS and G. RAVICHANDRAN, 'Particle velocimetry and photoelasticity applied to the study of dynamic sliding along frictionally-held bimaterial interfaces: Techniques and feasibility', SEM Experimental Mechanics, 46, 205-216 (2006). (Society for Experimental Mechanics, Hetenyi award for the best research paper published in Experimental Mechanics in 2006). pdf
  • G. LYKOTRAFITIS and A.J. ROSAKIS, 'Dynamic sliding of frictionally held bimaterial interfaces subjected to impact shear loading', Proceedings of the Royal Society A, 462, 2997-3026 (2006). pdf
  • G. LYKOTRAFITIS and A.J. ROSAKIS, 'Photoelastic study of sliding along frictionally held incoherent interfaces of homogeneous systems subjected to dynamic shear loading', International Journal of Fracture  pdf, 140, 213-233 (2006).
  • D. COKER, G. LYKOTRAFITIS, A. NEEDLEMAN and A.J. ROSAKIS, 'Frictional sliding modes along an interface between identical plates subject to shear impact loading', Journal of the Mechanics and Physics of Solids, 53, 884-922 (2005).  pdf
  • H.G. GEORGIADIS and G. LYKOTRAFITIS, 'Asymptotic solution for three-dimensional transient thermoelastic Rayleigh waves due to a thermal source', ASME Journal of Applied Mechanics, 72, 129-138 (2005).  pdf
  • G. LYKOTRAFITIS and H.G. GEORGIADIS, 'The three-dimensional steady-state thermo-elastodynamic problem of moving sources over a half space', International Journal of Solids and Structures, 40, 899-940 (2003). pdf
  • H.G. GEORGIADIS and G. LYKOTRAFITIS, 'A method based on the Radon transform for three-dimensional elastodynamic problems of moving loads', Journal of Elasticity, 65, 87-129 (2001).  pdf
  • G. LYKOTRAFITIS, H.G. GEORGIADIS and L.M. BROCK, 'Three-dimensional thermoelastic wave motions in a half-space under the action of a buried source', International Journal of Solids and Structures, 38, 4857-4878 (2001).  pdf
  • H.G. GEORGIADIS, I. VARDOULAKIS and G. LYKOTRAFITIS, 'Torsional surface waves in a gradient-elastic half-space', Wave Motion, 31, 333-348 (2000).  pdf

    • Book Chapters

  • A.J. ROSAKIS, K. XIA, G. LYKOTRAFITIS and H. KANAMORI, 'Dynamic shear rupture in frictional interfaces: speeds, directionality and modes', Treatise on Geophysics, Volume 4 - Earthquake Seismology: Fracture and Frictional Mechanics - Experimental Study I, Elsevier (2007).

    • Recent Conference Proceedings

  • M. BUDYANSKY, M. MADORMO and G. LYKOTRAFITIS, 'Coherent Gradient Sensing Microscopy: Microinferometric Technique for Quantitative Cell Detection', Proceedings of the Society for Experimental Mechanics Annual Conference & Exposition on Experimental and Applied Mechanics, Paper No. 209, Indianapolis, IN, June 2010.  pdf
  • J. MACIASZEK, G. LYKOTRAFITIS, 'Characterization of Erythrocytes from Healthy Individuals and from Patients with the Sickle Cell Trait', Proceedings of the 16th US National Congress of Theoretical and Applied Mechanics, Paper No. 1161, College Park, PA, June 2010.  pdf
  • H. LI, G. LYKOTRAFITIS, 'A Course-grain Molecular Dynamics Model for Sickle Hemoglobin Fibers and their Interactions', Proceedings of the 16th US National Congress of Theoretical and Applied Mechanics, Paper No. 763, College Park, PA, June 2010.  pdf
  • G. LYKOTRAFITIS, J. LI, S. SURESH, 'A Course-Grain Model for Red Blood Cell Membrane', USACM 10th US National Congress on Computational Mechanics, Columbus, OH, June 2009.  pdf
  • S. ZHANG, H. YUAN, J. LI, G. LYKOTRAFITIS, G. BAO, S. SURESH, 'Guiding Principles of Nanoparticle Uptake by Biological Cells', The 2009 Joint ASCE-ASME-SES Conference on Mechanics and Materials, Blackburg, VA, June 2009.  pdf
  • G. LYKOTRAFITIS, J. LI, S. SURESH, 'A Course-Grain Model for Erythrocyte Membrane', The 2009 Joint ASCE-ASME-SES Conference on Mechanics and Materials, Blackburg, VA, June 2009.  pdf
  • G. LYKOTRAFITIS, A.J. ROSAKIS, 'Rupture of Frictionally Held Incoherent Interfaces Under Dynamic Shear Loading', Proceedings of the 11 th International Conference on Fracture, Tourin, Italy, March 2005.  pdf
  • D. Coker, G. LYKOTRAFITIS, A. Needleman, A.J. ROSAKIS, 'Crack-like and Pulse-like Dynamic Frictional Sliding', Proceedings of the 11 th International Conference on Fracture, Tourin, Italy, March 2005.  pdf
  • G. LYKOTRAFITIS, A.J. ROSAKIS, 'Identifying Dynamic Rupture Modes in Frictional Interfaces', Proceedings of the Society for Experimental Mechanics Annual Conference & Exposition on Experimental and Applied Mechanics, Portland, OR, June 2005.  pdf
  • G. LYKOTRAFITIS, A.J. ROSAKIS, 'Sliding of Frictionally Held Incoherent Interfaces Under Dynamic Shear Loading', 2004 ASME/STLE International Joint Tribology Conference, Long Beach, CA, October 24-27, 2004.  pdf
  • G. LYKOTRAFITIS, A.J. ROSAKIS, 'Dynamic Rupture Frictionally Held Incoherent Interfaces Under Dynamic Shear Loading', Proceedings of the Society for Experimental Mechanics Annual Conference & Exposition on Experimental and Applied Mechanics, Costa Mesa, CA, June 2004.  pdf