When neutrophils detect and follow only the concentration gradient of the primary chemoattractant fMLP, the recruitment to the wound site is partial.
Response to a combination of the primary chemoattractant fMLP and the secondary chemoattractant LTB4, emitted from migrating neutrophils that essentially act as chemoattraction relays for neutrophils at larger distances from the wound, leads to an increased recruitment radius.
NCC and PLC Collective Migration Model
Interacting NCCs and PLCs without implementation of chemotaxis do not exhibit CCM.
Combination of direct pair-interaction and indirect interaction, via chemotaxis, of NCCs and PLCs causes CCM and the emergence of "chase-and-run" behavior.
Combination of direct pair-interaction and indirect interaction, via chemotaxis, of NCCs and PLCs causes CCM and the emergence of "chase-and-run" behavior in 3D.
